British researchers discovered genetic mechanism in the formation of neural networks that they say one day become a new treatment for stroke, Alzheimer's disease or brain tumors. In a research note in the journal "Nature Neuroscience," the researchers found the gene, called Sox9, a key to the development of neural stem cells in the human embryo - the primary cells that will form the brain or spinal tissue. In experiments on mice, they found that the use of these genes may initiate the development of stem cells, increasing the potential for the future in order to replace or renew the damaged brain cells in humans.
"By knowing that Sox9 gene plays a central role in the development of neural networks, we are getting closer to having the ability to control stem cells in the brain and grow several other types of nerve cells," said James Briscoe of the Medical Research Council UK, who led the research.
"The ability to correct the nerve cells are damaged can be a big leap in the millions of people with Alzheimer's, brain tumors associated with stem cells or stroke patients," Briscoe said in a statement, although the need for many more years before pengobatann to humans can be developed.
Human embryo begins to form a network of nerves two weeks after conception, it is clear the research team.
From that point until about five weeks, the neural network largely made up of neuroepithelial cells, which grow quickly and form the foundation of the brain and spinal cord. After this phase, various types of nerves and supporting cells that form the main neural network began to emerge. These cells derived from stem cells.
From that point until about five weeks, the neural network largely made up of neuroepithelial cells, which grow quickly and form the foundation of the brain and spinal cord. After this phase, various types of nerves and supporting cells that form the main neural network began to emerge. These cells derived from stem cells.
In their study, the team found that Sox9 is required Briscoe neuroepithelial cells to turn into stem cells itu.Sel it will always be needed to make the adult brain retain the ability, like the ability to renew themselves and distinguish themselves.
The research team also found that a gene called "Shh" Sox9 is required in order to work. Artificially add Sox9 or Shh into neuroepithelial cells on embryonic mice, researchers can begin the process of changing these cells into neural stem cells.
The research team also found that a gene called "Shh" Sox9 is required in order to work. Artificially add Sox9 or Shh into neuroepithelial cells on embryonic mice, researchers can begin the process of changing these cells into neural stem cells.
They also find, if there is a genetic disorder in Sox9, will become more difficult for rats to be able to renew the damaged nerve cells in the future. Potentials in various types of stem cells to the attention of many experts around the world for various diseases. But the technology is still considered controversial, partly because some application of stem cells taken from embryos or fetuses.
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